Oral desensitization in patients with chronic tophaceous gout and allopurinol hypersensitivity

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Chronic tophaceous gout in patients with psoriasis*

Psoriasis is a chronic inflammatory disease of multifactorial etiology influenced by genetic, immunological, and environmental factors. We report the case of a patient with psoriasis for more than 25 years who developed hyperuricemia and chronic tophaceous gout with unusual appearance. In psoriasis, hyperuricemia may occur by increased epidermal cell turnover, which accelerates purine metabolis...

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Chronic tophaceous gout.

A 44 year old man presented with a 15-day history of painful swelling of right middle finger, which was also red, warm, and tender. A tooth paste like, chalky substance was expressible on pressure from the swelling. The patient reported that he had occasional episodes of joint pains involving both small and large joints of the extremities. He denied a history of medication intake and past histo...

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[Chronic tophaceous gout].

A 51-year-old immigrant from the Caucasus had had chronic tophaceous gout for over 20 years, but had never been treated with anti-hyperuricemic drugs. He had developed large, multiple tophi in many locations, including both ankles and feet. The enormous size and unique location of the tophi caused considerable pain, and difficulty in standing and on walking. Since surgical removal of the tophi ...

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[Chronic tophaceous gout].

Forty-three-year old male, consumer of 2 litres (80 ounces) of beer every day for the past 21 years. Fifteen years ago, he presented acute pain along with monoarticular inflammation of the lower limbs. At first he presented 2-3 annual episodes of monoarthritis, which improved with non-steroidal anti-inflammatory drugs. The patient did not follow the pharmaceutical treatment or the hygienic-diet...

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Withdrawal of allopurinol in patients with gout.

The xanthine oxidase inhibitor allopurinol effectively lowers the plasma level of uric acid and the drug has become widely used in the treatment of gout, especially in patients with renal failure, uric acid calculi, or intolerance to uricosuric agents (Scott, Hall, and Grahame, 1966). Various theoretical complications of treatment have been considered from time to time, such as possible incorpo...

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ژورنال

عنوان ژورنال: Rheumatology

سال: 1999

ISSN: 1462-0324,1462-0332

DOI: 10.1093/rheumatology/38.1.85